The Econo Lodge in Hannibal is located in the heart of the city and is adjacent to I-72 and HWY 61. Mark Twain historical sites within minutes. The hotel features a complimentary Continental Breakfast. Several restaurants within a 5 minute drive. Impeccably clean, spacious rooms and friendly service bring back guests who visit each year. Earn FREE nights or flights by joining the easy Choice Frequent Traveller Program. Do not request non-smoking rooms.