Our Holiday Inn Express Hotel ® Lake City is located in the eastern section of the South Carolina in Florence County at the junction of US Highway 378 & US Highway 52, central to major destination cities. Lake City is the perfect hotel when traveling with a group, for business or pleasures. Or, a great stop-over if your traveling to the historical cities and beaches of South Carolina, with accessibility to US Highway 52 and I-95. Charleston, SC ® 89 Mi Columbia, SC - 78 Mi Florence, SC - 25 Mi Myrtle Beach, SC ® 63 Mi Santee, SC ® 59 Mi Sumter, SC ® 35 Mi Our city is the center of a thriving agricultural area, well known for tobacco farming and diversified industries, and home of Nan-Ya Plastics Corporation, and Lake City Community Hospital. We are within minutes of Lynch's River and less than one hour from Santee Copper Lakes, Pee-Dee and the Great Pee-Dee Rivers, well known to many great fisherman and water enthusiast. The Lake City and Florence woodlands and rivers attract avid hunters for ducks, quail, deer and other small game. If you®re a NASCAR fan, Darlington Motor Speedway is just 35 miles from Lake City. Darlington is the home of several prestigious annual races: Dodge Charger ® May Event Diamond Hill Plywood 500 ® May Event We specialize in small meetings and gathering accommodating up to twenty people. This hotel is committed to providing accessible facilities under the American Disabilities Act. If your accessibility needs are not met, please contact the Hotel Manager on Duty. Should you require additional information regarding accessible facilities for guests with disabilities, please call 1-800-Holiday (U.S. and Canada) or contact the hotel directly. For the hearing impaired, TDD service is available at 1-800-238-5544 within the U.S. and Canada.