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<< Back We're sorry, there are no hotels located in New Madrid, MO. Below is a list of the closest cities to New Madrid that have hotels, along with their distance from New Madrid: Marston, MO - 6.4 miles from New Madrid, MO Sikeston, MO - 20.4 miles from New Madrid, MO Charleston, MO - 25.3 miles from New Madrid, MO Hayti, MO - 27.2 miles from New Madrid, MO Dexter, MO - 27.7 miles from New Madrid, MO Caruthersville, MO - 28.7 miles from New Madrid, MO Union City, TN - 29.2 miles from New Madrid, MO Cairo, IL - 35.4 miles from New Madrid, MO Kennett, MO - 37.5 miles from New Madrid, MO Dyersburg, TN - 38.8 miles from New Madrid, MO Martin, TN - 41.6 miles from New Madrid, MO Poplar Bluff, MO - 49.5 miles from New Madrid, MO Cape Girardeau, MO - 49.7 miles from New Madrid, MO Blytheville, AR - 50.0 miles from New Madrid, MO Mayfield, KY - 50.7 miles from New Madrid, MO Ullin, IL - 51.5 miles from New Madrid, MO Metropolis, IL - 59.4 miles from New Madrid, MO Paducah, KY - 62.0 miles from New Madrid, MO Milan, TN - 63.5 miles from New Madrid, MO Change Destination / Dates  IHSAdvantage.com
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